SLC30A8, solute carrier family 30 member 8, 169026

N. diseases: 63; N. variants: 23
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7817754
rs7817754
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE Only one SNP (rs7817754) was significantly associated with incident T2D but a summary statistic based on all T2D-related traits identified 11 novel SNPs. 27896278 2016
dbSNP: rs770784511
rs770784511
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE <i>SLC30A8</i> gene 807C/T polymorphism was significantly associated with an increased T2</span>DM risk in the Chinese population. 29875737 2018
dbSNP: rs748727258
rs748727258
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94). 18498634 2008
dbSNP: rs6997279
rs6997279
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844 2018
dbSNP: rs6997279
rs6997279
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0011881
Disease:
Diabetic Nephropathy 		0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844 2018
dbSNP: rs6997279
rs6997279
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844 2018
dbSNP: rs6987643
rs6987643
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs531347476
rs531347476
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 0.700 GeneticVariation GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
dbSNP: rs4876369
rs4876369
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs4876369
rs4876369
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs4876369
rs4876369
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011849
Disease:
Diabetes Mellitus 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs4876369
rs4876369
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011847
Disease:
Diabetes 		0.010 GeneticVariation BEFREE Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale. 30457165 2019
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASDB Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455 2012
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASCAT Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. 31118516 2019
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASDB Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. 20581827 2010
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation BEFREE In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied. 20550665 2010
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASCAT Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. 20581827 2010
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.820 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation BEFREE A total of 15 SNPs were genotyped.Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05-1.27); P = 4.5 x 10(-3)] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14-1.40); P = 1.4 x 10(-5)] and rs7923837 [OR = 1.27 (95% CI 1.13-1.43); P = 1.0 x 10(-4)] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15-1.40); P = 1.9 x 10(-6)] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11-1.36); P = 8.1 x 10(-5)] and rs1470579 [OR = 1.18 (95% CI 1.07-1.31); P = 8.3 x 10(-4)] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17-1.41); P = 4.5 x 10(-7)] and rs7756992 [OR = 1.27 (95% CI 1.15-1.40); P = 9.8 x 10(-7)] in CDKAL1. 18477659 2008
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASCAT Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 26961502 2016
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs3802177
rs3802177
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASCAT Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455 2012